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DDI Potential of Major Pharmaceutical Excipients on Transporters and Enzymes

Download the Presentations from the 2023 Advanced In Vitro ADME Strategies: ICH Guidelines & Novel Methodologies Symposium.

On June 9, 2023, BioIVT hosted a symposium in Denmark featuring an array of BioIVT and industry experts discussing important topics relevant to ADME/Tox research. If you were unable to attend, a selection of the presentations is now available to download, including:

DDI Potential of Major Pharmaceutical Excipients on Transporters and Enzymes
Speaker: Mark Warren, PhD, Senior Director of Transporter Assay Services, BioIVT

Abstract: Excipients are “inactive” ingredients that are added to therapeutic drug products that are not intended to exert therapeutic effects by themselves. However, these excipients may inhibit intestinal transporters that can be responsible for enhancing or reducing the absorption of not only the drug that is administered along with the excipient, but also the absorption of co-medications that have never been tested with that excipient. Generic products may contain different excipients than the original branded medication, which may also contribute to unexpected drug-drug interactions. Numerous excipients were tested and shown to inhibit OATP2B1, an intestinal drug uptake transporter, as well as BCRP and P gp, intestinal drug efflux transporters.

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